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Recombinant Human IL-2 R alpha / CD25 Protein, His Tag, 100µg  

Recombinant Human IL-2 R alpha / CD25 Protein, His Tag, 100µg

Recombinant Human IL2RA /CD25 Protein, Glu 22 - Cys 213, expressed in human 293 cells (HEK293), His tag

Synonym: recombinant, human, protein, IL2RA, CD25, p55,IL2-RA, IL-2-RA

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Availability: within 7 days

390,00 €

Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

Recombinant Human IL-2 R alpha, His Tag (ILA-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Cys 213 (Accession # NP_000408).
Predicted N-terminus: Glu 22

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.6 kDa. The protein migrates as 34-46 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "A prognostic model incorporating inflammatory cells and cytokines for newly diagnosed multiple myeloma patients"
Ren, Xu, Li et al
Clin Exp Med (2023)
(2) "TGF-β2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma"
Lee, Nam, Go et al
Biomed Pharmacother (2023) 159, 114212
(3) "Promotion of IL‑17/NF‑κB signaling in autoimmune thyroid diseases"
Lu, Xing, Zhang et al
Exp Ther Med (2023) 25 (1), 51
Showing 1-3 of 1623 papers.