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Recombinant Human B7-H5 / Gi24 / VISTA Protein, His-Tag, 100µg  

Recombinant Human B7-H5 / Gi24 / VISTA Protein, His-Tag, 100µg

Recombinant Human B7-H5 / Gi24 / VISTA Protein (rh B7-H5 / Gi24 / VISTA) Phe 33 - Ala 194 was produced in human 293 cells (HEK293) fused with  a polyhistidine tag, His Tag (MALS verified)

Synonym: recombinant, human, protein B7-H5,SISP1,Gi24,VISTA

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Availability: within 7 days

364,00 €

Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment..

Recombinant Human B7-H5 /Gi24/VISTA Protein, His Tag (B75-H52H0) is expressed from human 293 cells (HEK293). It contains AA Phe 33 - Ala 194 (Accession # AAH20568).
Predicted N-terminus: Phe 33

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 20.0 kDa. The protein migrates as 33-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>90% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "Comprehensive characterization of B7 family members in NSCLC and identification of its regulatory network"
Xiao, Pang, Xiang et al
Sci Rep (2023) 13 (1), 4311
(2) "B7-H4 Further Stratifies Patients With Endometrial Cancer Exhibiting a Nonspecific Molecular Profile"
Zong, Yu, Mo et al
Arch Pathol Lab Med (2023)
(3) "Novel immune scoring dynamic nomograms based on B7-H3, B7-H4, and HHLA2: Potential prediction in survival and immunotherapeutic efficacy for gallbladder cancer"
Lv, Han, Wu et al
Front Immunol (2022) 13, 984172
Showing 1-3 of 33 papers.