kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Recombinant Cynomolgus / Rhesus macaque TIGIT Protein, 50µg  

Recombinant Cynomolgus / Rhesus macaque TIGIT Protein, 50µg

Recombinant Cynomolgus / Rhesus macaque TIGIT, AA Met 89 - Ile 208, expressed from human 293 cells (HEK293), His Tag (HPLC verified)

Synonym: recombinant, human, protein, TIGIT, VSIG9, VSTM3

More details


Availability: within 7 days

494,00 €

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Recombinant Cynomolgus / Rhesus macaque TIGIT, His Tag (TIT-C5223) is expressed from human 293 cells (HEK293). It contains AA Met 89 - Ile 208 (Accession # XP_015300911.1). In the region Met 89 - Ile 208,  the AA sequence of Cynomolgus and Rhesus macaque TIGIT are homologus.
Predicted N-terminus: Met 89

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 15.2 kDa. The protein migrates as 18-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>90% as determined by SDS-PAGE.
>90% as determined by SEC-HPLC.

Please refer to product data sheet.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Clinical and Translational Updates

(1) "TIGIT reverses IFN-α-promoted Th1-like Tregs via in-sequence effects dependent on STAT4"
Yu, Gu, Wang et al
Arthritis Res Ther (2023) 25 (1), 221
(2) "A circadian clock gene-related signature for predicting prognosis and its association with sorafenib response in hepatocellular carcinoma"
Liang, Ye, Li et al
Transl Cancer Res (2023) 12 (10), 2493-2507
(3) "PD1+TIGIT+2B4+KLRG1+ cells might underlie T-cell dysfunction in patients treated with BCMA-directed CAR-T therapy"
Mishra, Schmidt, Martell et al
Transplant Cell Ther (2023)
Showing 1-3 of 1368 papers.