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PKA substrate (Kemptide), 25 mg  

PKA substrate (Kemptide), 25 mg

PKA peptide substrate LRRASLG (Kemptide)

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PEP-PKA1-025

Availability: within 7 days

250,00 €

The synthetic heptapeptide LRRASLG (Kemptide) is a substrate corresponding to part of the phosphorylation site sequence in porcine liver pyruvate kinase. It is phosphorylated in vitro and in vivo by cAMP-dependent protein kinase (Km 10 µM) and in vitro by protein kinase C.

Amino acid sequence: LRRASLG-OH
Purity:                           >97% (HPLC-MS)
Molecular weight:         771.9 g/mol
Form:                             lyophilized solid

Product specific literature references:

Maller JL, Kemp BE, Krebs EG (1978) "In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP-dependent protein kinase." Proc Natl Acad Sci U S A. 75(1):248-51.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

Peer - Reviewed Citations

Wolter S1, Golombek M, Seifert R.(2011) Differential activation of cAMP- and cGMP-dependent protein kinases by cyclic purine and pyrimidine nucleotides.Biochem Biophys Res Commun.415(4):563-6.

Boonpawa R, Spenkelink A, Punt A, Rietjens IMCM. (2017) "Physiologically based kinetic modeling of hesperidin metabolism and its use to predict in vivo effective doses in humans." Mol Nutr Food Res.61(8).