TrkA peptide substrate, 1 mg

The synthetic peptide KKKSPGEYVNIEFG derived from IRS-1 (insulin receptor protein-1) can be used as a substrate for TrkA (cell surface transmembrane receptor tyrosine kinase for nerve growth factor) in in vitro kinase assays.

TrkA substrate peptide :    order-no. PEP-TRKA-001
Amino acid sequence.:       KKKSPGEYVNIEFG
Molecular Weight:              1596 g/mol
Shipment conditions:          Ambient temperature
Long Term Storage:           -20°C (AVOID FREEZE/THAW CYCLES)
Purity:                                 85% (by HPLC)
Appearance:                       Lyophilized solid

Product specific literature references:

Geetha T, Rege SD, Mathews SE, Meakin SO, White MF, Babu JR.(2013)  “Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells.” J Biol Chem. 288(33):23807-13.

Miranda C1, Greco A, Miele C, Pierotti MA, Van Obberghen E.(2001) „IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1.” J Cell Physiol. 86(1):35-46.

Bosc DG, Luscher B, Litchfield DW (1999) "Expression and regulation of protein kinase CK2 during the cell cycle" Mol Cell PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.