NSC 87877, 50 mg

NSC 87877 is a potent protein tyrosine phosphatase (PTP) inhibitor with selectivity for SHP-2 and SHP-1 (IC50 values are 0.32 and 0.36 µM). The inhibitor probably interacts with the catalytic cleft of the PTP domain. NSC 87877 displays lower activity for other PTPs (IC50 values are 1.7, 7.7, 65.6, 84.5 and 150.9 μM for PTP1B, HePTP, DEP1, CD45 and LAR).  In cell based assays NSC 87877 inhibits EGF-induced SHP-2 dependent Erk1/2 activation. 

Solubility: water to 50 mM, Molecular Weight:  459.5 g/mol, CAS number: 56932-43-5

Formula: C₁₉H₁₃N₃O₇S₂.

Product specific literature references:

Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. (2006) "Discovery of a novel shp2 protein tyrosine phosphatase inhibitor" Mol Pharmacol. 70(2):562-70.

Zhao XT, Qian YK, Chan AW, Madhavan R, Peng HB. (2007) "Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2" Dev Neurobiol.67(13):1789-801.

Qian YK, Chan AW, Madhavan R, Peng HB. (2008) "The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters." BMC Neurosci.23;9:70

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.