PTP1B, 50 µg

PTP-1B is part of the non transmembrane subfamily of classical protein tyrosine phosphatases. The protein consists of an N-terminal PTP-domain followed by two tandem proline-rich sequences and a C-terminal hydrophobic stretch, targeting the enzyme to the endoplasmatic reticulum. The catalytic PTP-domain contains a cysteine residue within its active site that mediates the nucleophilic attack on substrate phosphotyrosine residues. PTP1B negatively regulates several signalling pathways by dephosphorylating EGFR and PDGFR and has a prominent role in IR signalling and glucose homeostasis. Dysregulation of PTP1-B is associated with insulin resistance and diabetes and obesity.

Synonyms: Tyrosine-protein phosphatase non-receptor type 1, EC 3.1.3.48, Protein-tyrosine phosphatase 1B, PTP-1B, PTPN1, PTP1B

Protein Informations: Protein Tyrosine Phosphatase 1B, human recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 321 amino (aa 1-321) acids and having a molecular mass of 37.3 kDa. Protein concentration: 1.0 mg/ml, Purity: > 95% by SDS PAGE, Specific activity: 10.000 U*/mg

Ordering information: shipped on dry ice

Product specific literature:

Dub N, Tremblay ML. (2005) "Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer." Biochim Biophys Acta. 30; 1754 (1-2):108-17.

Stuible M, Doody KM, Tremblay ML. (2008) "PTP1B and TC-PTP: regulators of transformation and tumorigenesis." Cancer Metastasis Rev. 27(2):215-30.

Simoncic PD, McGlade CJ, Tremblay ML. (2006) "PTP1B and TC-PTP: novel roles in immune-cell signaling." Can J Physiol Pharmacol. 84(7):667-75.