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viral proteins

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Recombinant viral proteins

Six strains of coronaviruses (CoVs) that are able to infect humans have been identified until last year. HCoV-OC43, HCoV-229E, HCoV-NL63, and HCoVHKU1 are not highly pathogenic and only cause mild respiratory diseases. SARS-CoV and MERS-CoV have caused two large-scale pandemics. Before efficient antiviral drugs or vaccines are developed for SARS-CoV or MERS-CoV, another outbreak of pneumonia caused by a new coronavirus (2019-nCoV) has emerged in Wuhan since December 2019.

Coronaviruses are a group of enveloped positive-stranded RNA viruses that consist of four structural proteins including spike (S) glycoprotein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein. Spike glycoprotein is the most important surface protein of coronavirus, which can mediate the entrance to human respiratory epithelial cells by interacting with cell surface receptor angiotensin-converting enzyme 2 (ACE2).

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