kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Recombinant Human TIMP2/CSC-21K Protein, His-Tag, 50µg  

Recombinant Human TIMP2/CSC-21K Protein, His-Tag, 50µg

Recombinant Human CSC-21K /TIMP2 Protein, Cys 27 - Pro 220 was produced in human 293 cells (HEK293), His Tag

recombinant human protein, CSC-21K, TIMP2

More details


Availability: within 7 days

364,00 €

TIMP metallopeptidase inhibitor 2 also known as TIMP2, which belongs to the protease inhibitor I35 (TIMP) family. This family protein are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The TIMP family encompasses four members (TIMP1, TIMP2, TIMP3, TIMP4), and they inhibit most MMPs by forming non-covalent binary complex. In addition to an inhibitory role against metalloproteinases, TIMP2 has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, TIMP-2 may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Recombinant Human CSC-21K /TIMP2 Protein (rhTIMP2), His Tag (TI2-H5223) is expressed from human 293 cells (HEK293). It contains AA Cys 27 - Pro 220 (Accession # NP_003246.1).
Predicted N-terminus: Cys 27

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 22.6 kDa. The protein migrates as 23-26 kDa under reducing (R) condition (SDS-PAGE).

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.


Clinical and Translational Updates

(1) "Differences in metalloproteinases and their tissue inhibitors in the cerebrospinal fluid are associated with delirium"
Aksnes, Schibstad, Chaudhry et al
Commun Med (Lond) (2024) 4 (1), 124
(2) "Effects of artificial light with different spectral compositions on refractive development and matrix metalloproteinase 2 and tissue inhibitor of metalloproteinases 2 expression in the sclerae of juvenile guinea pigs"
Yuan, Li, Fan et al
Eur J Histochem (2024) 68 (3)
(3) "The role of Sirtuin 1 in regulation of fibrotic genes expression in pre-adipocytes"
Tanhapour, Nourbakhsh, Panahi et al
J Diabetes Metab Disord (2024) 23 (1), 1081-1091
Showing 1-3 of 8087 papers.