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Recombinant human EpCAM / TROP1 /CD326 Protein, His tag, 100µg  

Recombinant human EpCAM / TROP1 /CD326 Protein, His tag, 100µg

Recombinant Human EpCAM  / TROP1 / CD326 Protein, Gln24 - Lys265, expressed in human 293 cells (HEK293), His tag

Recombinant Human Protein, EPCAM, TACSTD1, TROP1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, GA733-2, HNPCC8, HNPCC-8, KS1, 4, KSA, M4S1, MIC18, MK1

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Availability: within 7 days

364,00 €

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.
Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

Recombinant Human EpCAM /CD326 Protein (rhEpCAM), His Tag (EPM-H5223) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Lys 265 (Accession # AAH14785.1).
Predicted N-terminus: Gln 24

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus
The protein has a calculated MW of 28.2 kDa. The protein migrates as 31-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 0.1 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Clinical and Translational Updates

(1) "CLO24-062: Aneuploid Epcam + Disseminated Tumor Cells (DTCs) Correlated With Liver Metastasis and Independently Predict Poor Survival in Small Cell Lung Cancer"
Zhang, Wang, Li et al
J Natl Compr Canc Netw (2024) 22 (2.5)
(2) "Role of regulatory T cells in mouse lung development"
Jiang, Lu, Wang et al
Exp Biol Med (Maywood) (2024) 249, 10040
(3) "PSMA2 promotes glioma proliferation and migration via EMT"
Zhang, Xiang, Chen et al
Pathol Res Pract (2024) 256, 155278
Showing 1-3 of 10078 papers.