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Recombinant Mouse EpCAM /CD326 Protein, His tag, 100µg  

Recombinant Mouse EpCAM /CD326 Protein, His tag, 100µg

Recombinant Mouse EpCAM /CD326 Protein, Gln 24 - Thr 266, produced in human 293 cells (HEK293), His tag

Recombinant Mouse Protein, EPCAM, TACSTD1, TROP1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK1

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Availability: within 7 days

312,00 €

EpCAM is also known as CO171A,; EGP; EGP40; GA7332; KSA; M4S; MIC18; MK1; TROP1; hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity.[1] The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.[2] Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported.[3] And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.[4]

Recombinant Mouse EpCAM /CD326 Protein (mouse EpCAM) Gln 24 - Thr 266 (Accession # AAH05618.1) was produced in human 293 cells (HEK293)

Molecular Characterization
mouse EpCAM, fused with 6×His tag at the N-terminus, has a calculated MW of 28.5 kDa. The predicted N-terminus is Gln 24. DTT-reduced Protein migrates as 37 kDa due to glycosylation.

Less than 1.0 EU per μg of the mouse EpCAM by the LAL method.

>98% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).


(1)Linnenbach, et al., 1993, Mol Cell Biol 13 (3): 1507–15.
(2)Akita H, et al., 2011, Oncogene., 30 (31): 3468-76.
(3)Winter MJ, et al., 2007, Mol Cell Biochem. 302(1-2):19-26.
(4)Schmidt M, et al., 2011, Breast Cancer Res Treat. 125(3):637-46.

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