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Recombinant human DPPIV/CD26 Protein, Fc Tag, 50µg  

Recombinant human DPPIV/CD26 Protein, Fc Tag, 50µg

Recombinant Human DPPIV /DPP4 /CD26 Protein, Asn29 - Pro766, produced in human 293 cells (HEK293), Fc Tag

Recombinant Human Protein, DPP4, ADABP, ADCP2, CD26, DPPIV, TP103

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Availability: within 7 days

408,00 €

Dipeptidyl peptidase-IV (DPPIV), also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.[1] The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides.[2] DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1.[3] DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.[4] DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

Recombinant Human DPPIV /DPP4 /CD26 Protein, With N-Fc Tag (rhDPPIV-Fc) Asn29 - Pro766 (Accession #NP_001926.2 ) was produced in human 293 cells (HEK293).

Molecular Characterization
rhDPPIV-Fc, fused with a Fc region of human IgG1 at the N-terminus and and has a calculated MW of 112 kDa expressed. Protein migrates as 90-120 kDa in reduced SDS-PAGE resulting from glycosylation.

Less than 1.0 EU endotoxin per μg rhDPPIV-Fc by the LAL method.

>95% purity as determined by SDS-PAGE of reduced rhDPPIV-Fc.

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4C-8C); After reconstitution under sterile conditions for 1 month (4C-8C) or 3 months (-20C to -70C).


(1) Kameoka J, et al.,1993, Science, 261 (5120): 466-9.
(2) Chen X, 2006, Adv. Exp. Med. Biol. 575: 27–32.
(3) Morimoto, C. et al., 1994, Proc. Natl. Acad. Sci. USA. 91: 9960-4.
(4) Havre PA, et al., 2008, Front. Biosci. 13: 1634–45.

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