Recombinant Cynomolgus CD24 Protein, Fc Tag, 100µg

Background
CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity

Source
Recombinant Cynomolgus CD24, Fc Tag (CD4-C5257) is expressed from human 293 cells (HEK293). It contains AA Thr 27 - Lys 54 (Accession # I7GKK1-1).
Predicted N-terminus: Thr 27

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 29.3 kDa. The protein migrates as 42-50 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

Endotoxin
Less than 1.0 EU per µg by the LAL method.

Purity
>90% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Reconstitution
See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70^°C for 3 months under sterile conditions after reconstitution.

Bioactivity
Please refer to product data sheet.

Clinical and Translational Updates

(1) "Assessing the causal relationship between circulating immune cells and abdominal aortic aneurysm by bi-directional Mendelian randomization analysis"
Ruan, Zhou, Wang et al
Sci Rep (2024) 14 (1), 13733
(2) "The genetic relationships between immune cell traits, circulating inflammatory proteins and preeclampsia/eclampsia"
Liu, Zhang, Du et al
Front Immunol (2024) 15, 1389843
(3) "Blockade of tumor cell-intrinsic PD-L1 signaling enhances AURKA-targeted therapy in triple negative breast cancer"
Takchi, Zhang, Jalalirad et al
Front Oncol (2024) 14, 1384277
Showing 1-3 of 4187 papers.