Recombinant Cynomolgus CD24 Protein, Fc Tag, 100µg

Background
CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity

Source
Recombinant Cynomolgus CD24, Fc Tag (CD4-C5257) is expressed from human 293 cells (HEK293). It contains AA Thr 27 - Lys 54 (Accession # I7GKK1-1). Predicted N-terminus: Thr 27

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 29.3 kDa. The protein migrates as 42-50 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

Endotoxin
Less than 1.0 EU per µg by the LAL method.

Purity
>90% as determined by SDS-PAGE.

Formulation
Supplied as a 0.22 μm filtered solution in PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally  trehalose are added as protectants before lyophilization.

Reconstitution
See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70^°C for 3 months under sterile conditions after reconstitution.

Bioactivity
Please refer to product data sheet.

Clinical and Translational Updates

(1) "Targeted surface marker screening on neuronal structures in the human choroid"
Wolfmeier, Heindl, Platzl et al
Exp Eye Res (2022)
(2) "Genetic profiling of different phenotypic subsets of breast cancer stem cells (BCSCs) in breast cancer patients"
Zekri, Bahnassy, Mourad et al
Cancer Cell Int (2022) 22 (1), 423
(3) "PARP1 controls the transcription of CD24 by ADP-ribosylating the RNA helicase DDX5 in pancreatic cancer"
Chen, Dai, Luo et al
Int J Biochem Cell Biol (2022)
Showing 1-3 of 3838 papers.