Products

Biaffin

Newsletter

kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Recombinant Mouse TROP-2 / TACSTD2 Protein, His Tag, 200 µg  

Recombinant Mouse TROP-2 / TACSTD2 Protein, His Tag, 200 µg

Recombinant Mouse TROP-2 / TACSTD2 Protein, AA Gln 25 - Gly 270, produced in human 293 cells (HEK293), His Tag

Synonym
recombinant, human, protein, TACSTD2, GA733-1, M1S1, TROP2

More details

TR2-M52H6-200

Availability: within 7 days

300,00 €

Background
TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

Source
Recombinant Mouse TROP-2, His Tag (TR2-M52H6) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Gly 270 (Accession # Q8BGV3-1). Predicted N-terminus: Gln 25

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.9 kDa. The protein migrates as 38-48 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

Endotoxin
Less than 1.0 EU per μg by the LAL method.

Purity
>90% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization.

Reconstitution
See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.

Bioactivity
Please refer to product data sheet.

References

(1) Simms A., et al., 2016, Diagn. Cytopathol. 44(1):26-31.(2) Fornaro M., et al., 1995, Int. J. Cancer. 62(5):610-618.