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Recombinant Human VEGF-D Protein, 100µg  

Recombinant Human VEGF-D Protein, 100µg

Recombinant Human VEGF-D Protein, Phe 93 - Ser 201, expressed from human 293 cells (HEK293), His Tag

Synonym: recombinant, human, protein, FIGF,VEGFD

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Availability: within 7 days

455,00 €

Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.

Recombinant Human VEGF-D Protein expressed from human 293 cells (HEK293). It contains AA Phe 93 - Ser 201 (Accession # AAH27948).
Predicted N-terminus: Phe 93

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 13.4 kDa. The protein migrates as 19-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "A cross-sectional study comparing the inflammatory profile of menstrual effluent vs. peripheral blood"
Naseri, Rosenberg-Hasson, Maecker et al
Health Sci Rep (2023) 6 (1), e1038
(2) "Adenoviral VEGF-DΔN ΔC gene therapy for myocardial ischemia"
Pajula, Lähteenvuo, Lähteenvuo et al
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(3) "Pre-surgery inflammatory and angiogenesis biomarkers as predictors of 12-month cancer-related distress: Results from the ColoCare Study"
Lindley, Gigic, Peoples et al
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Showing 1-3 of 1224 papers.