VEGF, 10 µg

VEGF family plays an integral role in angiogenesis, lymphangiogenesis, and vasculogenesis. The human VEGF family consists of six members: VEGF-A, the predominantly form, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and placental-derived growth factor (PlDF). VEGFs act as hetero- or homodimers by activating the tyrosine kinases VEGFR-1/Flt-1, VEGFR-2 (KDR/flk-1), and VEGFR-3.

Synonyms: Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGF, MGC70609

Protein informations: Vascular Endothelial Growth Factor, human recombinant produced in E. coli, is a double, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 38.2 kDa. The VEGF is purified by proprietary chromatographic techniques.

Purity: > 98% by SDS PAGE

Biological activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-8.0 ng/ml.

Product specific literature references:

Breen EC. (2007) "VEGF in biological control." J Cell Biochem. 15;102(6):1358-67.

Roskoski R Jr. (2007) "Vascular endothelial growth factor (VEGF) signaling in tumor progression."  Crit Rev Oncol Hematol. 62(3):179-213.

Warner-Schmidt JL, Duman RS. (2008) "VEGF as a potential target for therapeutic intervention in depression." Curr Opin Pharmacol. (1):14-9.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.