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Recombinant Human IL-23 alpha & IL-12 beta Heterodimer Protein,His Tag&Tag Free (MALS verified), 50 µg  

Recombinant Human IL-23 alpha & IL-12 beta Heterodimer Protein,His Tag&Tag Free (MALS verified), 50 µg

Recombinant Human IL-23 alpha & IL-12 beta Heterodimer Protein, Arg 20 - Pro 189 (IL23A) & Ile 23 - Ser 328 (IL12B), produced in human 293 cells (HEK293), His Tag&Tag Free (MALS verified)

Synonym: Recombinant huma protein,IL-23 alpha & IL-12 beta

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Availability: within 7 days

481,00 €

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Recombinant Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free (ILB-H52W5) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 189 (IL23A) & Ile 23 - Ser 328 (IL12B) (Accession # Q9NPF7-1 (IL23A) & P29460-1 (IL12B)).
Predicted N-terminus: His (IL23A) & Ile 23 (IL12B)

Molecular Characterization
Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23 alpha and IL-12 beta, has a calculated MW of 19.5 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta). Subunit IL-23 alpha is fused with a polyhistidine tag at the N-terminus and subunit IL-12 beta contains no tag. The reducing (R) protein migrates as 23 kDa (IL-23 alpha) & 40-45 kDa (IL-12 beta) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "Mycobacterium vaccae NCTC 11659, a Soil-Derived Bacterium with Stress Resilience Properties, Modulates the Proinflammatory Effects of LPS in Macrophages"
Holbrook, Zambrano, Wright et al
Int J Mol Sci (2023) 24 (6)
(2) "Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer"
Minohara, Imai, Matoba et al
Cancer Sci (2023) 114 (4), 1256-1269
(3) "Expression of B lymphocyte-induced maturation protein 1 (Blimp-1) in keratinocyte and cytokine signalling drives human Th17 response in psoriasis"
da Costa, Gardinassi, Veras et al
Arch Dermatol Res (2023) 315 (3), 481-490
Showing 1-3 of 84 papers.