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Recombinant Mouse IL-23 alpha & IL-12 beta Heterodimer Protein, 50µg  

Recombinant Mouse IL-23 alpha & IL-12 beta Heterodimer Protein, 50µg

Recombinant Mouse IL-23 alpha & IL-12 beta Heterodimer Protein, Val 22 - Ala 196 (IL23A) & Met 23 - Ser 335 (IL12B), produced in human 293 cells (HEK293), His Tag&Tag Free

recombinant, mouse, IL-23 alpha & IL-12 beta protein

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Availability: within 7 days

420,00 €

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Recombinant Mouse IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free (ILB-M52W7) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Ala 196 (IL23A) & Met 23 - Ser 335 (IL12B) (Accession # Q9EQ14-1 (IL23A) & P43432-1 (IL12B)).
Predicted N-terminus: His (IL23A) & Met 23 (IL12B)

Molecular Characterization
Mouse IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23A and IL-12B, has a calculated MW of 20.5 kDa (IL-23A) and 35.8 kDa (IL-12B). Subunit IL-23A is fused with a polyhistidine tag at the N-terminus and subunit IL-12B contains no tag. The reducing (R) protein migrates as 19 kDa (IL-23A) and 40-44 kDa (IL-12B) respectively due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>90% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet

Clinical and Translational Updates

(1) "Cytokine RNA In Situ Hybridization Permits Individualized Molecular Phenotyping in Biopsies of Psoriasis and Atopic Dermatitis"
Wang, Fogel, Murphy et al
JID Innov (2021) 1 (2), 100021
(2) "Predicted regulatory SNPs reveal potential drug targets and novel companion diagnostics in psoriasis"
Ruiz Ramírez, Flores-Saiffe Farías, Chávez Álvarez et al
J Transl Autoimmun (2021) 4, 100096
(3) "Interplay between NOD1 and TLR4 Receptors in Macrophages: Nonsynergistic Activation of Signaling Pathways Results in Synergistic Induction of Proinflammatory Gene Expression"
Budikhina, Murugina, Maximchik et al
J Immunol (2021) 206 (9), 2206-2220
Showing 1-3 of 61 papers.

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