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Recombinant Human IL-18 R1 / CD218a Protein, Fc Tag, 200µg  

Recombinant Human IL-18 R1 / CD218a Protein, Fc Tag, 200µg

Recombinant Human IL18R1 /CD218a Protein, Ala 19 - Arg 329, produced in human 293 cells (HEK293), Fc Tag

recombinant, human, protein, IL18R1, IL1RRP, CD218a, IL18Ra

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Availability: within 7 days

377,00 €

Interleukin-18 receptor 1 (IL18R1) is also known as CD218 antigen-like family member A (CD218a), IL1 receptor-related protein (IL-1Rrp or IL1R-rp), CDw218a, IL18Ra, IL1RRP, which belongs to the interleukin-1 receptor family. IL18R1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL18R1 is receptor for interleukin 18 (IL-18). IL18R1 binds to the agonist leads to the activation of NF-kappa-B, but does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

Recombinant Human IL18R1 /CD218a Protein, Fc Tag (IL1-H5259) is expressed from human 293 cells (HEK293). It contains AA Ala 19 - Arg 329 (Accession # AAH69575).
Predicted N-terminus: Ala 19

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 62.4 kDa. The protein migrates as 80-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "miRNA-323a-3p promoted intracranial, aneurysm-induced inflammation via AMPK/NF-κB signaling pathway by AdipoR1"
Sun, Liu, Yu
Adv Clin Exp Med (2022) 31 (11), 1243-1254
(2) "The relationship between disease activity and UDCA response criteria in primary biliary cholangitis: A cohort study"
Jones, Wetten, Barron-Millar et al
EBioMedicine (2022) 80, 104068
(3) "Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury"
Kim, Lee, Kim et al
J Clin Med (2021) 10 (21)
Showing 1-3 of 30 papers.