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Recombinant Human PD-L2 / B7-DC Protein, mouse IgG1 Fc Tag, 100µg  

Recombinant Human PD-L2 / B7-DC Protein, mouse IgG1 Fc Tag, 100µg

Recombinant Human PD-L2 / B7-DC Protein, Leu 20 - Pro 219, expressed from human 293 cells (HEK293), mouse IgG1 Fc Tag

Synonym: human, recombinant, protein, PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2

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Availability: within 7 days

377,00 €

Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Recombinant Human PD-L2, mouse IgG1 Fc Tag (PD2-H52A5) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Pro 219 (Accession # AAI13679).
Predicted N-terminus: Leu 20

Molecular Characterization
This protein carries a mouse IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 48.9 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "Balancing the Nanoscale Organization in Multivalent Materials for Functional Inhibition of the Programmed Death-1 Immune Checkpoint"
Paloja, Weiden, Hellmeier et al
ACS Nano (2023)
(2) "Comprehensive analysis of single-cell and bulk RNA-sequencing data identifies B cell marker genes signature that predicts prognosis and analysis of immune checkpoints expression in head and neck squamous cell carcinoma"
Wusiman, Li, Guo et al
Heliyon (2023) 9 (12), e22656
(3) "Linking tumor immune infiltrate and systemic immune mediators to treatment response and prognosis in advanced cervical cancer"
Rocha Martins, Luciano Pereira Morais, de Lima Galdino et al
Sci Rep (2023) 13 (1), 22634
Showing 1-3 of 1547 papers.


(1) "In Vitro Assays to Study PD-1 Biology in Human T Cells"
Authors: Tocheva, Anna S et al.
Journal: Current protocols in immunology vol 2020
Application: Flow cytometry