Recombinant Human LAIR2 / CD306 Protein, His Tag, 100 µg

Background
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) is also known as CD antigen CD306. LAIR2 contains one Ig-like C2-type (immunoglobulin-like) domain. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 / CD306 is thought to be secreted and may help modulate mucosal tolerance.

Source
Recombinant Human LAIR-2, His Tag (LA2-H5220) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Pro 152 (Accession # AAH69366). Predicted N-terminus: Gln 22

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 14.9 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin
Less than 1.0 EU per μg by the LAL method.
 
Purity
>95% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20^°C to -70^°C for 12 months in lyophilized state;
-70^°C for 3 months under sterile conditions after reconstitution.

Bioactivity
Please refer to product data sheet.

Clinical and Translational Updates

(1) "Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism"
Elsayed, Abdelazim, Darwish et al
Sci Rep (2023) 13 (1), 6
(2) "Increased concentration of soluble leukocyte-associated immunoglobulin-like receptor (LAIR) in sera from patients with blistering diseases: possible pathophysiological implications?"
Marchiano, Iervasi, Pesce et al
Minerva Med (2022)
(3) "Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1"
Vijver, Singh, Mommers-Elshof et al
Front Immunol (2021) 12, 733561
Showing 1-3 of 38 papers.