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Recombinant human CXADR / CAR Protein, His Tag, 100µg  

Recombinant human CXADR / CAR Protein, His Tag, 100µg

Recombinant Human CXADR / CAR Protein, Leu 20 - Gly 237, produced in human 293 cells (HEK293), His Tag

Recombinant, human protein, CXADR, CAR, CAR4/6, HCAR

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Availability: within 7 days

300,00 €

Coxsackie virus and adenovirus receptor (CXADR) also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human CXADR protein contains a signal sequence, a extracellular domain (ECD) with a V­ type (D1) and a C2­ type (D2) Ig­like domain, a  transmembrane segment and a intracellular domain. D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.[1-4]

Recombinant Human CXADR / CAR Protein (rhCXADR) Leu 20 - Gly 237 (Accession # NP_001329.1) was produced in human 293 cells (HEK293).

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 24.9 kDa. The protein migrates as 32-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg of the rhCXADR by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).



(1)Bergelson JM, et al., 1997, Science 275 (5304): 1320–3.
(2)Tomko RP, et al., 1997, Proc Natl Acad Sci U S A 94 (7): 3352–6.
(3)Patzke C, et al., 2010, Journal of Neuroscience 30 (8): 2897–2910.
(4)Raschperger, E. et al., 2006, Exp. Cell Res. 312: 1566-80.