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PSPH, 20  µg  

PSPH, 20 µg

Phosphoserine phosphatase

Synonyms: Phosphoserine phosphatase, EC, PSP, O-phosphoserine phosphohydrolase, PSPase, L-3-phosphoserine phosphatase, PSPH

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195,00 €

Phosphoserine phosphatase is a phosphohydrolase which catalyses the hydrolysis of that metabolizes the conversion of L-phosphoserine to L-serine. It requires a divalent cation such as Mg2+ for maximal activity and the hydrolysis of D- and L-phosphoserine is inhibited by L-, but not D-serine. No protein phosphatase activity has ever been reported for PSP. PSP plays a role in proliferation of embryonic and adult neural progenitors, at least partly through regulation of L-serine production.

Protein Informations: Phosphoserine Phosphatase is a single, non-glycosylated polypeptide chain containing 225 amino acids and having a molecular mass of 25 kDa. PSPH was overexpressed in E. coli and purified by conventional chromatography. Protein concentration: 1.0 mg/ml, Purity: > 95% by SDS PAGE

Ordering information: shipped on dry ice

Product specific literature:

Moro-Furlani AM, Turner VS, Hopkinson DA. (1980) "Genetical and biochemical studies on human phosphoserine phosphatase." Ann Hum Genet. 43 (4):323-33

Nakano I, Dougherty JD, Kim K, Klement I, Geschwind DH, Kornblum HI.(2007) "Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation." Stem Cells.25 (8):1975-84.

Hawkinson JE, Acosta-Burruel M, Ta ND, Wood PL. (1997) "Novel phosphoserine phosphatase inhibitors." Eur J Pharmacol. 22; 337 (2-3):315-24