8-pCPT-cGMP, 10 µmol

8-pCPT-cGMP is a selective activator of protein kinase G type I alpha, I beta and type II (cyclic GMP agonist) and of cGMP-gated ion channels. It has a higher activation potential compared to cGMP and an excellent cell membrane permeability as well as phosphodiesterase stability. This cGMP analog is a recommendable alternative to the widely used dibutyryl cGMP.

8-pCPT-cGMP:             order-no. PKE-8CPCG-010
Chemical name.:          8- ( 4- Chlorophenylthio) guanosine- 3', 5'- cyclic monophosphate
CAS No.                      51239-26-0
Formula:                      C16H14ClN5O7PS . Na
Molecular Weight:       509.8 g/mol
Purity:                         >97%
Appearance:             white solid
Solubility:                   water (50 mM), DMSO (250 mM), please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing

Synonyms: 8-CPT cyclic GMP, 8-pCPT cyclic GMP, 8-CPT-cGMP, 8-pCPT cGMP

Product specific literature references:

Kumar R, Namiki T, Joyner RW (1997) "Effects of cGMP on L-type calcium current of adult and newborn rabbit ventricular cells" Cardiovasc. Res. 33(3):573-82

Suhasini M, Li H, Lohmann SM, Boss GR, Pilz RB (1998) "Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway" Mol Cell Biol 18(12):6983-94.

Smolenski A, Poller W, Walter U, Lohmann SM (2000) "Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I" J. Biol. Chem. 275(33):25723-32

Kawai F, Miyachi E (2001) "Modulation by cGMP of the voltage-gated currents in newt olfactory receptor cells" Neurosci Res. 39(3):327-37

Fritsch RM, Saur D, Kurjak M, Oesterle D, Schlossmann J, Geiselhoringer A, Hofmann F, Allescher HD (2004) "InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle" J. Biol. Chem. 279(13):12551-9. 2004

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.