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Recombinant human TIMP1 Protein, His tag, 50µg  

Recombinant human TIMP1 Protein, His tag, 50µg

Recombinant Human TIMP1 Protein, Cys 24-Ala207, expressed in human 293 cells (HEK293), His tag

recombinant, human protein, TIMP1, TIMP-1, CLGI, EPA, EPO, FLJ90373, HCI, TIMP, TIMP metallopeptidase inhibitor 1

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Availability: within 7 days

420,00 €

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. This protein a member of the TIMP family.There are four members of the family, TIMP1,TIMP2,TIMP3 and TIMP4. TIMP1 is a glycoprotein with a molecular mass of 28 kDa produced by a wide range of cell types. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.[1]

Human TIMP1, His Tag (TI1-H5226) is expressed from human 293 cells (HEK293). It contains AA Cys 24 - Ala 207 (Accession # P01033-1).
Predicted N-terminus: Cys 24

Molecular Characterization
rhTIMP1 contains C-terminal polyhistidine tag and has a calculated MW of 24 kDa. DTT-reduced protein migrates as 28-32 kDa polypeptide in SDS-PAGE.

Less than 1.0 EU per μg of the rhTIMP1 by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).



(1) Hornebeck W (2004). Pathol. Biol. 51 (10): 569–73