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Recombinant Monkeypox virus (strain Zaire-96-I-16) E8L Protein, His Tag , 50µg  

Recombinant Monkeypox virus (strain Zaire-96-I-16) E8L Protein, His Tag , 50µg

Recombinant Monkeypox virus (strain Zaire-96-I-16) E8L Protein, AA Met 1 - Thr 275, expressed from human 293 cells (HEK293), His Tag

Synonyms: Recombinant, protein, E8L, monkey pox

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Availability: within 7 days

585,00 €

Monkeypox is a rare zoonosis caused by monkeypox virus, which has become the most serious orthpoxvirus and consists of complex double stranded DNA. The cases are mostly in central and western Africa. The pathogenesis of monkeypox is that the virus invades the body from respiratory mucosa , multiplies in lymphocytes, and incurs into blood producing transient venereal toxemia. after the virus multiplies in cells, the cells can invade the blood and propagate to the skin of the whole body, causing lesions. E8L can Binds to chondroitin sulfate on the cell surface to provide virion attachment to target cell.

Recombinant Monkeypox virus (strain Zaire-96-I-16) E8L, His Tag (E8L-M52H3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Thr 275 (Accession # Q8V4Y0-1).
Predicted N-terminus: Met 1

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 33.7 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>90% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Please refer to product data sheet.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Clinical and Translational Updates

(1) "A Vaccine Strategy Based on the Identification of an Annular Ganglioside Binding Motif in Monkeypox Virus Protein E8L"
Fantini, Chahinian, Yahi
Viruses (2022) 14 (11)
(2) "Inhibition of monkeypox virus replication by RNA interference"
Alkhalil, Strand, Mucker et al
Virol J (2009) 6, 188
(3) "MFG-E8 in the retina and retinal pigment epithelium of rat and mouse"
Burgess, Abrams, Nagata et al
Mol Vis (2006) 12, 1437-47
Showing 1-3 of 3 papers.