Recombinant Human ROR2 / NTRKR2 Protein, full ECD, His tag, 50 µg

Background
Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is a homodimer protein, which can binds YWHAB or interact with WTIP. ROR2 may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development.

Source
Recombinant Human ROR2, His Tag (RO2-H52E5) is expressed from human 293 cells (HEK293). It contains AA Glu 34 - Gly 403 (Accession # NP_004551.1).
Predicted N-terminus: Glu 34

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 43.2 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin
Less than 1.0 EU per μg by the LAL method.

Purity
>95% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization.

Reconstitution
See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70^°C for 3 months under sterile conditions after reconstitution

Bioactivity
Please refer to product data sheet.

Clinical and Translational Updates

(1) "Association of baseline ROR1 and ROR2 gene expression with clinical outcomes in the I-SPY2 neoadjuvant breast cancer trial"
Parker, Shatsky, Schwab et al
Breast Cancer Res Treat (2023)
(2) "WNT7A deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension"
Chakraborty, Nathan, Orcholski et al
Eur Respir J (2023)
(3) "Retraction: Wnt5A regulates the expression of ROR2 tyrosine kinase receptor in ovarian cancer cells"

Biochem Cell Biol (2023)
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