Recombinant Mouse ROR2 / NTRKR2 Protein, Fc Tag, 100 µg

Background
Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is a homodimer protein, which can binds YWHAB or interact with WTIP. ROR2 may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development.

Source
Recombinant Mouse ROR2, Fc Tag (RO2-M5253) is expressed from human 293 cells (HEK293). It contains AA Glu 34 - Gly 403 (Accession # Q9Z138-1).
Predicted N-terminus: Glu 34

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 67.6 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin
Less than 1.0 EU per μg by the LAL method.
 
Purity
>95% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70^°C for 3 months under sterile conditions after reconstitution.

Clinical and Translational Updates

(1) "ROR2 promotes invasion and chemoresistance of triple-negative breast cancer cells by activating PI3K/AKT/mTOR signaling"
DA, Ge, Shi et al
Oncol Res (2024) 32 (7), 1209-1219
(2) "Characterization of Wnt Signaling Pathway Aberrations in Metastatic Prostate Cancer"
Choi, Pan, Elliott et al
Mol Cancer Res (2024)
(3) "Genomic insights into adaptation to bipedal saltation and desert-like habitats of jerboas"
Chai, Chong, Yin et al
Sci China Life Sci (2024)
Showing 1-3 of 651 papers.