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Recombinant human CSF1R /CD115 Protein, His tag, 200µg  

Recombinant human CSF1R /CD115 Protein, His tag, 200µg

Recombinant Human M-CSF R / CSF1R /CD115 Protein (Ile20 - Glu512), produced in human 293 cells (HEK293), His tag

Recombinant Human Protein, CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR

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Availability: within 7 days

276,00 €

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the type III subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. [1] Increased levels of CSF1R1 are found in microglia in Alzheimer\'s disease and after brain injuries. The increased receptor expression causes microglia to become more active.[2] Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.[3-5]

Recombinant Human CSF1R /CD115 Protein (rhCSF1R) Ile20 - Glu512 (Accession # NP_005202.2) was produced in human 293 cells (HEK293)

Molecular Characterization
rhCSF1R, fused with a C-terminal 6×his tag and has a calculated MW of 55.1 kDa. The predicted N-terminus is Ile 20. DTT-reduced protein migrates as 80-95 kDa polypeptide in SDS-PAGE.

Less than 1.0 EU per μg of the rhCSF1R by the LAL method.

>96% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).

Immobilized Human M-CSF R, His Tag (Cat. No. CSR-H5228) at 5 μg/mL (100 μL/well) can bind Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) with a linear range of 2-31 ng/mL (QC tested).


(1) Ridge, et al., 1990, Proceedings of the National Academy of Sciences 87 (4): 1377–80.
(2) Mitrasinovic, O. M., 2005, Journal of Neuroscience 25 (17): 4442–51.
(3) Tamimi, R. M., 2008, Cancer Research 68 (1): 18–21.
(4) Pollard, J. W., 1994, Proceedings of the National Academy of Sciences 91 (20): 9312–6.
(5) Sapi, Eva, 2004, Experimental Biology and Medicine 229 (1): 1–11.

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