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Recombinant Mouse PCSK9 Protein, His Tag, 100 µg  

Recombinant Mouse PCSK9 Protein, His Tag, 100 µg

Recombinant Mouse PCSK9 Protein, Gln 35 - Gln 694, produced in human 293 cells (HEK293), His Tag

recombinant, mouse, protein, PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9

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Availability: within 7 days

420,00 €

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Recombinant Mouse PCSK9, His Tag (PC9-M5228) is expressed from human 293 cells (HEK293). It contains AA Gln 35 - Gln 694 (Accession # AAH38085.1).
Predicted N-terminus: Gln 35

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‑covalent interactions and with a calculated MW of 13.9 kDa and 58.2 kDa respectively. The protein migrates as 17 kDa and 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by Furin"
Susan-Resiga, Girard, Essalmani et al
J Biol Chem (2021)
(2) "Impact of PCSK9 Immunization on Glycemic Indices in Diabetic Rats"
Momtazi-Borojeni, Jaafari, Abdollahi et al
J Diabetes Res (2021) 2021, 4757170
(3) "Association of Serum Anti-PCSK9 Antibody Levels with Favorable Postoperative Prognosis in Esophageal Cancer"
Ito, Hiwasa, Oshima et al
Front Oncol (2021) 11, 708039
Showing 1-3 of 4199 papers.
Please refer to product data sheet.