kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Recombinant human spleen associated tyrosine kinase SYK, 10 µg  

Recombinant human spleen associated tyrosine kinase SYK, 10 µg

Recombinant human spleen associated tyrosine kinase,SYK, full length, amino acids M1-N635, N-erminal GST-HIS6 fusion protein, active enzyme

Alternate names: recombinant, human, protein, spleen tyrosine kinase, Tyrosine-Protein Kinase SYK, P72-Syk

More details


Availability: on stock

450,00 €

Background: SYK protein kinaseis widely expressed in hematopoietic cells and is involved in cellular responses to extracellular antigens and antigen-immunoglobulin complexes and thus of particular importance to the initiation of inflammatory responses. Spleen tyrosine kinase (SYK) mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). SYK is a non-receptor tyrosine kinase, which contains two SRC homology 2 (SH2)-domains and a kinase domain. Mammals also express the SYK-related molecule ZAP70, the expression of which is mostly confined to the T and NK cell lineages.

Theoretical MW (SYK) 104.4 kDa (fusion proteins)
Expression system: Baculovirus infected Sf9 cells
Purification: One-step affinity purification using glutathione agarose
Storage buffer:  50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol
Protein concentration: 0.094 mg/ml (Bradford method using BSA as standard protein)
Method for determination of Km value & specific activity: Filter binding assay MSFC membrane
Specific activity : 20.000 pmol/mg min

Ordering information: shipped on dry ice

Entrez Gene ID: 6850 UniProtKB: P43405

Product specific literature

Attila Mócsai, Jürgen Ruland, Victor L. J. Tybulewicz (2010) “The SYK tyrosine kinase: a crucial player in diverse biological functions” Nat Rev Immunol. 10(6): 387–402

Robert L. Geahlen (2014)  “Getting Syk: Spleen Tyrosine Kinase as a Therapeutic Target”, Trends Pharmacol Sci. 35(8): 414–422.