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Recombinant Human Gremlin / GREM1 Protein, Fc Tag, 100µg  

Recombinant Human Gremlin / GREM1 Protein, Fc Tag, 100µg

Recombinant Human Gremlin / GREM1 (Lys 25 - Asp 184), expressed from human 293 cells (HEK293), Fc tag

recombinant, human, protein, GREM1,CKTSF1B1,DAND2,DRM,PIG2

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Availability: within 7 days

372,00 €

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

Recombinant Human Gremlin / GREM1, Fc Tag (GR1-H5254) is expressed from human 293 cells (HEK293). It contains AA Lys 25 - Asp 184 (Accession # NP_037504).
Predicted N-terminus: Lys 25

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 44.2 kDa. The protein migrates as 48-60 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 150 mM NaCl, pH7.5 with 1 mM EDTA. Normally trehalose is added as protectant before lyophilization.

Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Please refer to product data sheet.


(1) Deletion of Gremlin-2 alters estrous cyclicity and disrupts female fertility in mice
Rydze, Patton, Briley et al
Biol Reprod (2021)
(2) Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin
Kawagishi-Hotta, Hasegawa, Inoue et al
Regen Ther (2021) 18, 191-201
(3) Decreased gremlin 1 expression in women with BMI ≥35 kg/m2 is mediated by interleukin 10 and interleukin 1β in the follicular fluid
Kim, Kim, Lucien et al
F S Sci (2020) 1 (1), 16-26
Showing 1-3 of 475 papers.
Please refer to product data sheet.