CHK1/2 substrate, 1 mg

The synthetic peptide KKKVSRSGLYRSPSMPENLNRPR can be used as a substrate for checkpoint kinases CHK1 and CHK2 in in vitro kinase assays. Its sequence is derived from cdc25C.

Purity: 90-95% (HPLC)

Molecular weight: 2701 g/mol

Form: solid

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.

Product specific literature references:

O\'Neill T, Giarratani L et al. (2002) Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J Biol Chem 277:16102-15.

Peer - Reviewed Citations

Koledova Z1, Kafkova LR, Krämer A, Divoky V. (2010) "DNA damage-induced degradation of Cdc25A does not lead to inhibition of Cdk2 activity in mouse embryonic stem cells." Stem Cells. 28(3):450-61.