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Background: 8-Br-cGMP is an activator of cGMP-dependent protein kinases I a, I ß & type II and cGMP-dependent ion channels (cyclic GMP agonist). It has an increased metabolical stability compared to cGMP, but is not completely stable as often stated.
Chemical name.: 8-Bromoguanosine- 3',5'-cyclic monophosphate, (8-Br-cGMP)
Formula: C10H10BrN5O7P.Na
Molecular Weight: 446.1 g/mol
Long Term Storage: -20°C
Purity: >98%
Appearance: White lyophilized powder
Solubility: water (200 mM), DMSO (0 mM) Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.
Rapoport RM, Draznin MB, Murad F (1982) "Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP" Proc. Natl. Acad. Sci. USA 79(21):6470-4
Lincoln TM (1983) "Effects of nitroprusside and 8-bromo-cyclic GMP on the contractile activity of the rat aorta" J. Pharmacol. Exp. Ther. 224(1):100-7
Cheung DW, MacKay MJ (1985) "The effects of sodium nitroprusside and 8-bromo-cyclic GMP on electrical and mechanical activities of the rat tail artery" Br. J. Pharmacol. 86(1):117-24
Choi J, Farley JM (1998) "Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells" J. Pharmacol. Exp. Ther. 285(2):588-94
PLEASE NOTE: This product is designed for research purposes and can only be delivered toacademic and business customers.
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