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Background: The second messenger cyclic AMP activates the holo enzyme complex of the cAMP dependent protein kinase PKA, the Rap1 guanine-nucleotide-exchange factor Epac, cAMP-gated ion channels, CAP protein and some other target receptors. The 8-Br-cAMP has an increased hydrolytical stability and membrane permeability compared to unmodified cAMP.
Chemical name.: 8-Bromoadenosine- 3',5'-cyclic monophosphate (8-Br-cAMP)
CAS number: 76939-46-3
Formula: C10H10BrN5O6P Na
Molecular Weight: 430.1 g/mol
Long Term Storage: -20°C
Purity: >98%
Appearance: White lyophilized powder
Solubility: water (200 mM), DMSO (200 mM) Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.
Ogreid D, Ekanger R, Suva RH, Miller JP, Doskeland SO (1989) "Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs" Eur. J. Biochem. 181(1):19-31
Ringler GE, Kao LC, Miller WL, Strauss JF (1989) "Effects of 8-bromo-cAMP on expression of endocrine functions by cultured human trophoblast cells. Regulation of specific mRNAs" Mol. Cell. Endocrinol. 61(1):13-21
Schwede F, Christensen A, Liauw S, Hippe T, Kopperud R, Jastorff B, Doskeland SO (2000) "8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II" Biochemistry 39(30):8803-12.
Wang Y, Adjaye J.(2011) "A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells."Stem Cell Rev. 7(2):331-41.
Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomi Y, Nakamura H, Koizumi S, Yachie A (2012) "Phosphodiesterase inhibitors suppress Lactobacillus casei cell-wall-induced NF-κB and MAPK activations and cell proliferation through protein kinase A--or exchange protein activated by cAMP-dependent signal pathway." ScientificWorldJournal:748572.
Sugimoto N, Miwa S, Ohno-Shosaku T, Tsuchiya H, Hitomi Y, Nakamura H, Tomita K, Yachie A, Koizumi S. (2011) "Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells." Neurosci Lett. 497(1):55-9.
Wemhöner K, Kanyshkova T, Silbernagel N, Fernandez-Orth J, Bittner S, Kiper AK, Rinné S, Netter MF, Meuth SG, Budde T, Decher N (2015) "An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities." Front Mol Neurosci. 2015 Nov 3;8:63.
PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.
Recombinant human cAMP-dependent protein kinase: PKA, RI alpha, 25 µg - 295,00 €
Recombinant human cAMP-dependent protein kinase: PKA, holo type I alpha, 25 µg - 295,00 €
Recombinant cAMP-dependent protein kinase: PKA, holo type II alpha, 25 µg - 295,00 €
cAMP, 500 µmol (~176 mg) - 70,00 €
8-Cl-cAMP, 10 µmol (~4 mg) - 127,00 €
8-CPT-cAMP, 100 µmol - 109,00 €
DB-cAMP, 100 µmol - 59,00 €
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