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Forskolin, 50 mg  

Forskolin, 50 mg

Forskolin, from Coleus forskohlii

Synonyms: colforsin
cell permeable stimulator of adenylate cyclase activity

More details

PKE-FORS-050

Availability: on stock

300,00 €

Background: Forskolin, is a cell permeable diterpenoid isolated from Coleus forskohlii.  Forskolin has a unique ability to stimulate adenylate cyclase activity and increase intracellular cyclic adenosine monophosphate (cAMP) thus activating cAMP-dependent protein kinase and other cAMP receptor proteins.

Chemical formula: C22H34O7
Molecular weight: 410.5 g/mol
Purity: >99% (HPLC)
Appearance: solid
Solubility: Soluble in anhydrous DMSO, acid ethyl ester or 100% ethanol
CAS number: 66575-29-9

Product specific literature references:

Seamon KB, Daly JW (1981) "Forskolin: a unique diterpene activator of cyclic AMP-generating systems" J. Cyclic Nucleotide Res. 7(4):201-24.

Fradkin JE, Cook GH, Kilhoffer MC, Wolff J (1982) "Forskolin stimulation of thyroid adenylate cyclase and cyclic 3\',5\'-adenosine monophosphate accumulation" Endocrinology 111(3):849-56

Barber R, Goka TJ (1985) "Adenylate cyclase activity as a function of forskolin concentration" J. Cyclic Nucleotide Protein Phosphor. Res. 10(1):23-9

Laurenza A, Sutkowski EM, Seamon KB (1989) "Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?" Trends Pharmacol. Sci. 10(11):442-7.

Product Citations:

Pavlikova N, Kortner TM, Arukwe A. (2010) "Peroxisome proliferator-activated receptors, estrogenic responses and biotransformation system in the liver of salmon exposed to tributyltin and second messenger activator." Aquat Toxicol. 99(2):176-85.

Röck R, Mayrhofer JE, Bachmann V, Stefan E. (2015) "Impact of kinase activating and inactivating patient mutations on binary PKA interactions."Front Pharmacol. 18;6:170.

PLEASE NOTE: Our highly pure research chemicals are provided only to academic and business customers for research use. This product has not been approved for any other purposes including, without limitation, diagnostic or therapeutic purposes, for use in preparation of food or pharmaceutical products nor for administration to humans. We do not supply private customers or non-research organizations with this product.