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cGMP, 100 µmol (~37 mg)  

cGMP, 100 µmol (~37 mg)

Guanosine- 3', 5'- cyclic monophosphate (cyclic GMP), sodium salt

activator of protein kinase G isozymes, cGMP-dependent ion channels as well as cGMP-responsive phosphodiesterases

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The second messenger cyclic GMP is an activator of protein kinase G isozymes, cGMP-dependent ion channels as well as cGMP-responsive phosphodiesterases. Cyclic GMP is metabolized rapidly in the presence of corresponding phosphodiesterases.  Sodium salt. Molecular weight 367.2 g/mol. Formula: Formula C10H11N5O7P. Na

cGMP:                         order-no. PKE-CGMP-100
Chemical name:          Guanosine- 3', 5'- cyclic monophosphate
Formula:                     C10H11N5O7P . Na
CAS No.                     40732-48-7
Molecular Weight:      367.2 g/mol
Purity:                        >98%
Appearance:              white solid
Solubility:                    water (200 mM), DMSO (0 mM), please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.

Product specific literature references:

Weber ET, Gannon RL, Rea MA (1995) "cGMP-dependent protein kinase inhibitor blocks light-induced phase advances of circadian rhythms in vivo" Neurosci. Lett. 197(3):227-30

Ruth P, Pfeifer A, Kamm S, Klatt P, Dostmann WR, Hofmann F(1997) "Identification of the amino acid sequences responsible for high affinity activation of cGMP kinase Ialpha" J. Biol. Chem. 272(16):10522-8

Chu DM, Corbin JD, Grimes KA, Francis SH (1997) "Activation by cyclic GMP binding causes an apparent conformational change in cGMP-dependent protein kinase J. Biol. Chem. 272(50):31922-8

Rybalkin SD, Rybalkina IG, Shimizu-Albergine M, Tang XB, Beavo JA (2003) "PDE5 is converted to an activated state upon cGMP binding to the GAF A domain" EMBO J. 22(3):469-78.

Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA (2003) "Cyclic GMP phosphodiesterases and regulation of smooth muscle function" Circ. Res. 93(4):280-91.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.