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Recombinant porcine FcRn/FCGRT & B2M Heterodimer Protein, 50 µg  

Recombinant porcine FcRn/FCGRT & B2M Heterodimer Protein, 50 µg

Recombinant Porcine FcRn/FCGRT & B2M Heterodimer Protein, Asp 16 - Ser 289 (FCGRT) and & Val 21 - His 118 (B2M), produced in human 293 cells (HEK293), His tag, Strep II-tag

recombinant porcine protein FcRN & B2M,FCGRT & B2M

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Availability: within 7 days

420,00 €

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

Recombinant Porcine FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (FCM-P5280) is expressed from human 293 cells (HEK293). It contains AA Asp 16 - Ser 289 (FCGRT) & Val 21 - His 118 (B2M) (Accession # Q6XAV9 (FCGRT) & Q07717 (B2M)).
Predicted N-terminus: Asp 16 (FCGRT) & Val 21 (B2M)

Molecular Characterization
Porcine FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, produced by co-expression of FCGRT and B2M, has a calculated MW of 32.3 kDa (FCGRT) and 12.8 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus and subunit Beta-2 microglobulin (B2M) is fused with a Strep II tag at the C-terminus. The reducing (R) protein migrates as 36 kDa (FCGRT) and 15 kDa (B2M) respectively.

Less than 1.0 EU per μg of the Rat FcRn / FCGRT & B2M by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Contact us for customized product form or formulation.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).

Immobilized Ipilumimab at 5 μg/mL (100 μL/well) can bind Porcine FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (Cat. No. FCM-P5280) with a linear range of 10-78 ng/mL (QC tested).


(1) Goebl NA., et al., 2008, Mol. Biol. Cell 19 (12): 5490–505.
(2) Lee TY., et al., 2008, Clin. Cancer Res. 14 (5): 1487–93.
(3) Güssow D., et al., 1987, J. Immunol. 139 (9): 3132–8.
(4) Gorevic P.D., et al., 1986, Proc. Natl. Acad. Sci. U.S.A. 83:7908-7912.

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