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Recombinant human FGFR1 /CD331 Protein, His tag, 200µg  

Recombinant human FGFR1 /CD331 Protein, His tag, 200µg

Recombinant Human FGF R1 /CD331 Protein, Arg22-Ile376, expressed in human 293 cells (HEK293), His tag (SPR verified)

Synonym
Recombinant Human Protein, FGFR1, BFGFR, CD331, CEK, FGFBR, FLG, HBGFR, N-SAM, FLT2, H2, KAL2, FLJ14326

More details

FG1-H5223-200

Availability: within 7 days

420,00 €

Background
Fibroblast growth factor receptor 1 (FGFR1) is also known as basic fibroblast growth factor receptor 1(BFGFR1), FMS-like tyrosine kinase, CD331, and is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. This protein is one of several fibroblast growth factor receptors, which are related proteins that are involved in important processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing, and embryonic development.The FGFR1 protein spans the cell membrane, so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. This positioning allows the FGFR1 protein to interact with specific growth factors outside the cell and to receive signals that help the cell respond to its environment. When growth factors attach to the FGFR1 protein, the receptor triggers a cascade of chemical reactions inside the cell that instruct the cell to undergo certain changes, such as maturing to take on specialized functions. The FGFR1 protein is thought to play an important role in the development of the nervous system. This protein may also help regulate the growth of long bones, such as the large bones in the arms and legs [1-2].

Source
Recombinant Human FGF R1, His Tag (FG1-H5223) is expressed from human 293 cells (HEK293). It contains AA Arg 22 - Ile 376 (Accession # P11362-7).
Predicted N-terminus: Arg 22

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 41.2 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin
Less than 1.0 EU per μg of the protein by LAL method.

Purity
>95% as determined by SDS-PAGE.

Bioactivity
Please refer to product data sheet.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Reconstitution
See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Clinical and Translational Updates

(1) "Exposure of male mice to perfluorooctanoic acid induces anxiety-like behaviors by increasing corticotropin-releasing factor in the basolateral amygdala complex"
Wang, Zhang, Shi et al
Chemosphere (2022) 287 (Pt 3), 132170
(2) "Intraindividual Long-term Immune Marker Stability in Plasma Samples Collected in Median 9.4 Years Apart in 304 Adult Cancer-free Individuals"
Späth, Wu, Krop et al
Cancer Epidemiol Biomarkers Prev (2021) 30 (11), 2052-2058
(3) "Efficacy and Selectivity of FGF2-Saporin Cytosolically Delivered by PCI in Cells Overexpressing FGFR1"
Vikan, Kostas, Haugsten et al
Cells (2021) 10 (6)
Showing 1-3 of 125 papers.

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