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Recombinant human FGFR4 /CD334 Protein, His tag, 200µg  

Recombinant human FGFR4 /CD334 Protein, His tag, 200µg

Recombinant Human FGFR4 /CD334 Protein, Leu22-Asp369, expressed in human 293 cells (HEK293), His tag

Synonym
Recombinant Human Protein, FGFR4, FGFR-4, CD334, JTK2, MGC20292, TKF, fibroblast growth factor receptor 4

More details

FG4-H5228-200

Availability: within 7 days

420,00 €

Background
Fibroblast growth factor receptor 4 (FGFR4) is also known as CD334, JTK2, hydroxyaryl-protein kinase, TKF, protein-tyrosine kinase . The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.[1-2]

Source
Recombinant Human FGFR4 /CD334 Protein (rhFGFR4) Leu22-Asp369 (Accession # AAH11847) was expressed in human 293 cells (HEK293)

Molecular Characterization
rhFGFR4, fused with 6×his tag at the C-terminus and has a calculated MW of 40 kDa. The predicted N-terminus is Leu 22. In DTT-reduced SDS-PAGE, protein migrates as 60 kDa.

Endotoxin
Less than 1.0 EU per μg of the protein by LAL method.

Purity
>98% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Reconstitution
See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage
Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).

References

(1) Eswarakumar VP, et al. (2005). Cytokine Growth Factor Rev. Apr;16(2):139-49.
(2) Wang J, et al. (2004). Clin Cancer Res. Sep 15;10(18 Pt 1):6169-78.

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