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Recombinant Mouse IL-13 R alpha 1 Protein, Fc Tag, 200µg  

Recombinant Mouse IL-13 R alpha 1 Protein, Fc Tag, 200µg

Recombinant Mouse IL13RA1 Protein, Ala 26 - Thr 340, produced in human 293 cells (HEK293), Fc Tag

Synonym
recombinant, mouse, protein, IL13RA1, CD213A1, IL-13Ra, NR4, RP13-128O4.2, IL13Rα1

More details

IL1-M5258-200

Availability: within 7 days

276,00 €

Background
Interleukin 13 receptor, alpha 1 is also known as IL13RA1, NR4 and CD213A1 (cluster of differentiation 213A1), The IL13 Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. Human and mouseIL13Rα1 share 76% aa sequence identity. IL13RA1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

Source
Recombinant Mouse IL13RA1 Protein,C-Fc Tag (Mouse IL13RA1 Fc Chimrea) Ala 26 - Thr 340 (Accession # NP_598751) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 62.7 kDa. The protein migrates as 67-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin
Less than 1.0 EU per μg of the Mouse IL13RA1 Fc Chimrea by the LAL method.

Purity
>95% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Reconstitution
See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Bioactivity
Please refer to product data sheet.

References

(1) Transcriptome and Function of Novel Immunosuppressive Autoreactive Invariant Natural Killer T Cells That Are Absent in Progressive Multiple Sclerosis
Carrión, Liu, Hadi et al
Neurol Neuroimmunol Neuroinflamm (2021) 8 (6)
(2) Anti-Inflammatory Therapeutic Approaches to Prevent or Delay Post-Traumatic Osteoarthritis (PTOA) of the Knee Joint with a Focus on Sustained Delivery Approaches
Khella, Horvath, Asgarian et al
Int J Mol Sci (2021) 22 (15)
(3) Haplopine Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice and TNF-α/IFN-γ-Induced Inflammation in Human Keratinocyte
Kim, Kim, Jegal et al
Antioxidants (Basel) (2021) 10 (5)
Showing 1-3 of 173 papers.
Please refer to product data sheet.