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Recombinant Mouse CTLA-4 / CD152 Protein, His-Tag, 200µg  

Recombinant Mouse CTLA-4 / CD152 Protein, His-Tag, 200µg

Recombinant Mouse CTLA-4 / CD152 Protein (Mouse CTLA-4, His Tag) Glu 36 - Phe 162 was produced in human 293 cells (HEK293).

Synonym: recombinant, mouse, protein, CTLA4,CD152,CELIAC3,GRD4,GSE,ICOS,IDDM12

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Availability: within 7 days

234,00 €

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

Recombinant Mouse CTLA-4, His Tag (CT4-M52H5) is expressed from human 293 cells (HEK293). It contains AA Glu 36 - Phe 162 (Accession # NP_033973).
Predicted N-terminus: Glu 36

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus
The protein has a calculated MW of 15.9 kDa. The protein migrates as 23-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "The microbial metabolite desaminotyrosine enhances T-cell priming and cancer immunotherapy with immune checkpoint inhibitors"
Joachim, Göttert, Sax et al
EBioMedicine (2023) 97, 104834
(2) "Histopathologic Manifestations of Immune Checkpoint Inhibitor Therapy-Associated Gastrointestinal Tract Injury: A Practical Review"
Mitchell, Karamchandani
Surg Pathol Clin (2023) 16 (4), 703-718
(3) "In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases"
Kerzel, Giacca, Beretta et al
Cancer Cell (2023)
Showing 1-3 of 13081 papers.


(1) "Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy"
Authors: Galstyan A, et al
Journal: Nat Commun 2019
Application: ELISA

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