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Aurora kinases play key roles in centrosome maturation, spindle assembly, and chromosome segregation during cell division. While only one kinase is present in yeast, three different aurora kinases have been found so far in mammalian cells (AuroraA, AuroraB and AuroraC). The three mitotic serine/threonine kinases fulfil different functions. Whereas AuroraA plays important roles in centrosome maturation and bipolar spindle formation, AuroraB is required for chromosome bi-orientation and cytokinesis. The third member, AuroraC, is specifically expressed in male germline during meiosis. The three human kinases share a very conserved C-terminal catalytic domain, but each of them possesses an N-terminal that is different in size and in sequence. AuroraA and AuroraB are coincidently overexpressed in various human cancers, suggesting that aurora kinases may play a role in oncogenic transformation.
Recombinant human protein kinase Aurora A, serine threonine kinase, active enzyme, purity > 80 % by SDS-PAGE
Theoretical MW: 76.3 kDa (fusion proteins)
Expression system: Baculovirus infected Sf9 cells
Storage buffer: 50 mM Tris-HCl, pH 8.0; 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol
Protein concentration: 0.25 mg/ml (Bradford method using BSA as standard protein)
Specific activity: 129,000 pmol/mg x min
Activation: This kinase was not activated by special procedures
Entrez Gene ID: 6790
UniProtKB: O14965
Ordering information: shipped on dry ice
Gautschi O, Heighway J, Mack PC, Purnell PR, Lara PN Jr, Gandara DR. (2008) "Aurora kinases as anticancer drug targets. Clin Cancer Res. 14(6):1639-48.
Barr AR, Gergely F. (2007) "Aurora-A: the maker and breaker of spindle poles." J Cell Sci. 120(Pt 17):2987-96.
Taylor S, Peters JM. (2008) "Polo and Aurora kinases: lessons derived from chemical biology." Curr Opin Cell Biol.; 20(1):77-84.
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