CDK2 substrate, 10 mg

The synthetic peptide HHASPRK is is a very specific substrate for cyclin-dependent kinase 2 (Cdk2) Cdk2/CyclinA in in vitro kinase assays.

Amino acid sequence: HHASPRK-OH
Purity:                          >95% (HPLC-MS)
Molecular weight:        831.0 g/mol
Form:                           lyophilized solid

Product specific literature references:

Brown NR, Noble ME, Endicott JA, Johnson LN. (1999) "The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases" Nat Cell Biol. (7):438-43.

Reiko Honda, Edward D Lowe, Elena Dubinina, Vicky Skamnaki, Atlanta Cook, Nick R Brown, Louise N Johnson (2005) “The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles”EMBO J. 9; 24(3): 452–463.

Li J, Vervoorts J, Carloni P, Rossetti G, Lüscher B.(2017)“Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinant.” BMC Bioinformatics;18(1):15

Wood DJ, Korolchuk S, Tatum NJ, Wang LZ, Endicott JA, Noble MEM, Martin MP (2019)“Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.” Cell Chem Biol. 2019;26(1):121-130.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.