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The second messenger cyclic AMP activates the holo enzyme complex of the cAMP dependent protein kinase PKA, the Rap1 guanine-nucleotide-exchange factor Epac, cAMP-gated ion channels, CAP protein and some other target receptors. The 8-Cl-cAMP is a site selective cyclic AMP analogue with high selectivity for protein kinase A type I. It induces growth inhibition and differentiation in cultured cancer cell lines.
Chemical name: 8-Chloroadenosine- 3', 5'-cyclic monophosphate (8-Cl-cAMP)
Formula: C10H10ClN5O6P . Na
Molecular Weight: 363.7 . 23.0 g/mol
Purity: >99%
Appearance: White lyophilized powder
Solubility: water (200 mM), DMSO (200 mM) Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.
Ally S, Tortora G, Clair T, Grieco D, Merlo G, Katsaros D, Ogreid D, Doskeland SO, Jahnsen T, Cho-Chung YS (1988) "Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3\',5\'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth" Proc. Natl. Acad. Sci. U S A 85(17):6319-22
Tortora G, Ciardiello F, Ally S, Clair T, Salomon DS, Cho-Chung YS (1989) "Site-selective 8-chloroadenosine 3\',5\'-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts" FEBS Lett. 242(2):363-7
Rohlff C, Clair T, Cho-Chung YS (1993) "8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells" J. Biol. Chem. 268(8):5774-82
PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.
Recombinant human cAMP-dependent protein kinase: PKA, RI alpha, 25 µg - 295,00 €
Recombinant human cAMP-dependent protein kinase: PKA, holo type I alpha, 25 µg - 295,00 €
Recombinant cAMP-dependent protein kinase: PKA, holo type II alpha, 25 µg - 295,00 €
8-Br-cAMP, 100 µmol - 66,00 €
cAMP, 500 µmol (~176 mg) - 70,00 €
8-CPT-cAMP, 100 µmol - 109,00 €
DB-cAMP, 100 µmol - 59,00 €
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