8-CPT-cAMP, 100 µmol

8-CPT-cAMP is a lipophilic activator of both cAMP- and cGMP- dependent protein kinase. It has a higher activation potential compared to cAMP and excellent cell membrane permeability, improved phosphodiesterase stability and high site selectivity preferring site B of cAMP-dependent protein kinase type II.  This analogue is not selective but activates cGMP-dependent protein kinase as well. In addition, it increases basal cGMP level by inhibition of PDE V.

8CPT-cAMP :         order-no. PKE-8CPCA-100
CAS No.                93882-12-3
Chemical name.:    8-(4-Chlorophenylthio) adenosine-3',5'-cyclic monophosphate
Formula:               C16H14ClN5O6PS . Na
Molecular Weight:     493.8 g/mol
Purity:                   >98%
Appearance:        white solid
Solubility:              water (50 mM), DMSO (75 mM) Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.

Product specific literature references:

Peters DJ, Bominaar AA, Snaar-Jagalska BE, Brandt R, Van Haastert PJ, Ceccarelli A, Williams JG, Schaap P (1991) "Selective induction of gene expression and second-messenger accumulation in Dictyostelium discoideum by the partial chemotactic antagonist 8-p-chlorophenylthioadenosine 3\',5\'-cyclic monophosphate" Proc. Natl. Acad. Sci. U S A. 88(20):9219-23.

Sandnes D, Jacobsen FW, Refsnes M, Christoffersen T (1996) "8-bromo-cAMP and 8-CPT-cAMP increase the density of beta-adrenoceptors in hepatocytes by a mechanism not mimicking the effect of cAMP" Pharmacol. Toxicol. 79(1):15-22

Parvathenani LK, Buescher ES, Chacon-Cruz E, Beebe SJ (1998) "Type I cAMP-dependent protein kinase delays apoptosis in human neutrophils at a site upstream of caspase-3" J. Biol. Chem. 273(12):6736-43

Product Citations:

Saito T1, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomi Y, Nakamura H, Koizumi S, Yachie A.
 (2012) "Phosphodiesterase inhibitors suppress Lactobacillus casei cell-wall-induced NF-κB and MAPK activations and cell proliferation through protein kinase A--or exchange protein activated by cAMP-dependent signal pathway." ScientificWorldJournal. 2012;748572.

Sugimoto N, Miwa S, Tsuchiya H, Hitomi Y, Nakamura H, Yachie A, Koizumi S (2013) "Targeted activation of PKA and Epac promotes glioblastoma regression in vitro."Mol Clin Oncol. 2013 Mar;1(2):281-285.

PLEASE NOTE: This product is designed for research purposes and can only be delivered toacademic and business customers.