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The second messenger cyclic AMP activates the holo enzyme complex of the cAMP dependent protein kinase PKA, the Rap1 guanine-nucleotide-exchange factor Epac, cAMP-gated ion channels, CAP protein and some other target receptors. It is metabolized rapidly by cyclic nucleotide-dependent phosphodiesterases.
Chemical name: Adenosine 3', 5'-cyclic monophosphate (cAMP)
Formula: C10H11N5O6P . Na
Molecular Weight: 351.2 g/mol
Long Term Storage: -20°C
Purity: >99% (HPLC)
Appearance: White solid
Solubility: water (200 mM), DMSO (200 mM) Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.
Scott JD (1991) "Cyclic nucleotide-dependent protein kinases" Pharmacol Ther. 50(1):123-45
de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL (1998) "Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP." Nature. 396(6710):474-7
Rich TC, Fagan KA, Nakata H, Schaack J, Cooper DM, Karpen JW (2000) "Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion" J. Gen. Physiol. 116(2):147-61
de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL (2000) "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs." J. Biol. Chem. 275(27):20829-36
PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.
Recombinant human cAMP-dependent protein kinase: PKA, RI alpha, 25 µg - 295,00 €
Recombinant human cAMP-dependent protein kinase: PKA, holo type I alpha, 25 µg - 295,00 €
Recombinant cAMP-dependent protein kinase: PKA, holo type II alpha, 25 µg - 295,00 €
8-Br-cAMP, 100 µmol - 66,00 €
8-Cl-cAMP, 10 µmol (~4 mg) - 127,00 €
8-CPT-cAMP, 100 µmol - 109,00 €
DB-cAMP, 100 µmol - 59,00 €
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