CDKs

Cyclin dependent kinases (CDKs)

Cdks are the catalytic subunits of serine/threonine protein kinases which are involved in the progression through the cell cycle.The catalytic activity of these kinases requires interaction with cyclins. These molecules are synthesized and degraded during the cell cycle in a cyclical fashion. Cdk-cyclin complexes are activated by phosphorylation in their activation loop by CAKs (Cdk activating kinase).